Publication (All)
136. Mori D, Inami C, Ikeda R, Sawahata M, Urata S, Yamaguchi ST, Kobayashi Y, Fujita K, Arioka Y, Okumura H, Kushima I, Kodama A, Suzuki T, Hirao T, Yoshimi A, Sobue A, Ito T, Noda Y, Mizoguchi H, Nagai T, Kaibuchi K, Okabe S, Nishiguchi K, Kume K, Yamada K, Ozaki N.
Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature
Transl Psychiatry. 2024 May 28;14(1):216. doi: 10.1038/s41398-024-02952-6.
135. Okabe S.
Development and Application of Technology for Neural Circuit Visualization - Secondary Publication
JMA J. 2024 Apr 15;7(2):185-189. doi: 10.31662/jmaj.2024-0019. Epub 2024 Apr 5.
134. Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T.
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
Elife. 2024 Mar 26;12:RP89376. doi: 10.7554/eLife.89376.
133. Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H.
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms
Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721. Epub 2023 Jun 14.
132. Kamei R,Okabe S.
In vivo imaging of the phagocytic dynamics underlying efficient clearance of adult-born hippocampal granule cells by ramified microglia
Glia. 2023 Aug;71(8):2005-2023. doi: 10.1002/glia.24379. Epub 2023 Apr 27. PMID: 37102766
131. Urata S, Okabe S.
Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy
Anat Sci Int. 2023 Feb 11. doi: 10.1007/s12565-023-00703-z. Epub ahead of print. PMID: 36773194.
130. Nozawa O, Miyata M, Shiotani H, Kameyama T, Komaki R, Shimizu T, Kuriu T, Kashiwagi Y, Sato Y, Koebisu M, Aiba A, Okabe S, Mizutani K, Takai Y.
Necl2/3-mediated mechanism for tripartite synapse formation
Development 2023 Feb 15;150(4):dev200931. doi: 10.1242/dev.200931. Epub 2023 Feb 22. PMID: 36458527.
129. Maruoka H, Kamei R, Mizutani S, Liu Q, Okabe S.
Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice.
J Vis Exp. 2022 Aug 23;(186). doi: 10.3791/64111. PMID: 36094267.
128. Kamei R, Urata S, Maruoka H, Okabe S.
In vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus.
J Vis Exp. 2022 Jul 6;(185). doi: 10.3791/64104. PMID: 35876553.
127. Terashima H, Minatohara K, Maruoka H, Okabe S.
Imaging neural circuit pathology of autism spectrum disorders: autism-associated genes, animal models and the application of in vivo two-photon imaging.
Microscopy (Oxf) 2022 Feb 18;71(Supplement_1):i81-i99. doi: 10.1093/jmicro/dfab039. PMID: 35275183.
126. Endo M, Maruoka H, Okabe S.
Advanced Technologies for Local Neural Circuits in the Cerebral Cortex.
Front Neuroanat. 2021 Nov 3;15:757499. doi: 10.3389/fnana.2021.757499. PMID: 34803616; PMCID: PMC8595196.
125. Quaglio G, Toia P, Moser EI, Karapiperis T, Amunts K, Okabe S, Poo MM, Rah JC, Koninck Y, Ngai J, Richards L, Bjaalie JG.
The International Brain Initiative: enabling collaborative science.
Lancet Neurol. 2021 Dec;20(12):985-986. doi: 10.1016/S1474-4422(21)00389-6. PMID: 34800415.
124. Morris K, Nami M, Bolanos JF, Lobo MA, Sadri-Naini M, Fiallos J, Sanchez GE, Bustos T, Chintam N, Amaya M, Strand SE, Mayuku-Dore A, Sakibova I, Biso GMN, DeFilippis A, Bravo D, Tarhan N, Claussen C, Mercado A, Braun S, Yuge L, Okabe S, Taghizadeh-Hesary F, Kotliar K, Sadowsky C, Chandra PS, Tripathi M, Katsaros V, Mehling B, Noroozian M, Abbasioun K, Amirjamshidi A, Hossein-Zadeh GA, Naraghi F, Barzegar M, Asadi-Pooya AA, Sahab-Negah S, Sadeghian S, Fahnestock M, Dilbaz N, Hussain N, Mari Z, Thatcher RW, Sipple D, Sidhu K, Chopra D, Costa F, Spena G, Berger T, Zelinsky D, Wheeler CJ, Ashford JW, Schulte R, Nezami MA, Kloor H, Filler A, Eliashiv DS, Sinha D, DeSalles AAF, Sadanand V, Suchkov S, Green K, Metin B, Hariri R, Cormier J, Yamamoto V, Kateb B.
Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental Disorders Through Neurotech Innovations and Policies.
J Alzheimers Dis. 2021;83(4):1563-1601. doi: 10.3233/JAD-215190. PMID: 34487051.
123. Tamada K, Fukumoto K, Toya T, Nakai N, Awasthi JR, Tanaka S, Okabe S, Spitz F, Saitow F, Suzuki H, Takumi T.
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
Nat Commun. 2021 Jul 1;12(1):4056. doi: 10.1038/s41467-021-24359-3. PMID: 34210967; PMCID: PMC8249516.
122. Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S.
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Nat Commun. 2021 Mar 23;12(1):1848. doi: 10.1038/s41467-021-22059-6.
121. Obashi K, Taraska JW, Okabe S.
The role of molecular diffusion within dendritic spines in synaptic function
J Gen Physiol. 2021 Apr 5;153(4):e202012814. doi: 10.1085/jgp.202012814.
120. Kashiwagi Y, Okabe S.
Imaging of spine synapses using super-resolution microscopy
Anat Sci Int. 2021 Jan 18. doi: 10.1007/s12565-021-00603-0. Online ahead of print.
119. Parajuli LK, Urakubo H, Takahashi-Nakazato A, Ogelman R, Iwasaki H, Koike M, Kwon HB, Ishii S, Oh WC, Fukazawa Y, Okabe S.
Geometry and the Organizational Principle of Spine Synapses along a Dendrite
eNeuro2020 Oct 27;7(6):ENEURO.0248-20.2020. doi: 10.1523/ENEURO.0248-20.2020. Print Nov-Dec 2020.
118. Okabe, S.
Regulation of actin dynamics in dendritic spines: Nanostructure, molecular mobility, and signaling mechanisms
Mol Cell Neurosci.2020 Dec;109:103564. doi: 10.1016/j.mcn.2020.103564. Epub 2020 Oct 20.
Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature
Transl Psychiatry. 2024 May 28;14(1):216. doi: 10.1038/s41398-024-02952-6.
135. Okabe S.
Development and Application of Technology for Neural Circuit Visualization - Secondary Publication
JMA J. 2024 Apr 15;7(2):185-189. doi: 10.31662/jmaj.2024-0019. Epub 2024 Apr 5.
134. Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah ND, Meltzer HY, Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang FL, Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef IA, Crabtree GR, Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker LJ, Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang BK, Otabi H, Yoshida Y, Toyoda A, Komiyama NH, Grant SGN, Ida-Eto M, Narita M, Matsumoto KI, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato DX, Inoue YU, Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T.
Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment
Elife. 2024 Mar 26;12:RP89376. doi: 10.7554/eLife.89376.
133. Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H.
Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms
Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721. Epub 2023 Jun 14.
132. Kamei R,Okabe S.
In vivo imaging of the phagocytic dynamics underlying efficient clearance of adult-born hippocampal granule cells by ramified microglia
Glia. 2023 Aug;71(8):2005-2023. doi: 10.1002/glia.24379. Epub 2023 Apr 27. PMID: 37102766
131. Urata S, Okabe S.
Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy
Anat Sci Int. 2023 Feb 11. doi: 10.1007/s12565-023-00703-z. Epub ahead of print. PMID: 36773194.
130. Nozawa O, Miyata M, Shiotani H, Kameyama T, Komaki R, Shimizu T, Kuriu T, Kashiwagi Y, Sato Y, Koebisu M, Aiba A, Okabe S, Mizutani K, Takai Y.
Necl2/3-mediated mechanism for tripartite synapse formation
Development 2023 Feb 15;150(4):dev200931. doi: 10.1242/dev.200931. Epub 2023 Feb 22. PMID: 36458527.
129. Maruoka H, Kamei R, Mizutani S, Liu Q, Okabe S.
Simultaneous Imaging of Microglial Dynamics and Neuronal Activity in Awake Mice.
J Vis Exp. 2022 Aug 23;(186). doi: 10.3791/64111. PMID: 36094267.
128. Kamei R, Urata S, Maruoka H, Okabe S.
In vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus.
J Vis Exp. 2022 Jul 6;(185). doi: 10.3791/64104. PMID: 35876553.
127. Terashima H, Minatohara K, Maruoka H, Okabe S.
Imaging neural circuit pathology of autism spectrum disorders: autism-associated genes, animal models and the application of in vivo two-photon imaging.
Microscopy (Oxf) 2022 Feb 18;71(Supplement_1):i81-i99. doi: 10.1093/jmicro/dfab039. PMID: 35275183.
126. Endo M, Maruoka H, Okabe S.
Advanced Technologies for Local Neural Circuits in the Cerebral Cortex.
Front Neuroanat. 2021 Nov 3;15:757499. doi: 10.3389/fnana.2021.757499. PMID: 34803616; PMCID: PMC8595196.
125. Quaglio G, Toia P, Moser EI, Karapiperis T, Amunts K, Okabe S, Poo MM, Rah JC, Koninck Y, Ngai J, Richards L, Bjaalie JG.
The International Brain Initiative: enabling collaborative science.
Lancet Neurol. 2021 Dec;20(12):985-986. doi: 10.1016/S1474-4422(21)00389-6. PMID: 34800415.
124. Morris K, Nami M, Bolanos JF, Lobo MA, Sadri-Naini M, Fiallos J, Sanchez GE, Bustos T, Chintam N, Amaya M, Strand SE, Mayuku-Dore A, Sakibova I, Biso GMN, DeFilippis A, Bravo D, Tarhan N, Claussen C, Mercado A, Braun S, Yuge L, Okabe S, Taghizadeh-Hesary F, Kotliar K, Sadowsky C, Chandra PS, Tripathi M, Katsaros V, Mehling B, Noroozian M, Abbasioun K, Amirjamshidi A, Hossein-Zadeh GA, Naraghi F, Barzegar M, Asadi-Pooya AA, Sahab-Negah S, Sadeghian S, Fahnestock M, Dilbaz N, Hussain N, Mari Z, Thatcher RW, Sipple D, Sidhu K, Chopra D, Costa F, Spena G, Berger T, Zelinsky D, Wheeler CJ, Ashford JW, Schulte R, Nezami MA, Kloor H, Filler A, Eliashiv DS, Sinha D, DeSalles AAF, Sadanand V, Suchkov S, Green K, Metin B, Hariri R, Cormier J, Yamamoto V, Kateb B.
Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental Disorders Through Neurotech Innovations and Policies.
J Alzheimers Dis. 2021;83(4):1563-1601. doi: 10.3233/JAD-215190. PMID: 34487051.
123. Tamada K, Fukumoto K, Toya T, Nakai N, Awasthi JR, Tanaka S, Okabe S, Spitz F, Saitow F, Suzuki H, Takumi T.
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
Nat Commun. 2021 Jul 1;12(1):4056. doi: 10.1038/s41467-021-24359-3. PMID: 34210967; PMCID: PMC8249516.
122. Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S.
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Nat Commun. 2021 Mar 23;12(1):1848. doi: 10.1038/s41467-021-22059-6.
121. Obashi K, Taraska JW, Okabe S.
The role of molecular diffusion within dendritic spines in synaptic function
J Gen Physiol. 2021 Apr 5;153(4):e202012814. doi: 10.1085/jgp.202012814.
120. Kashiwagi Y, Okabe S.
Imaging of spine synapses using super-resolution microscopy
Anat Sci Int. 2021 Jan 18. doi: 10.1007/s12565-021-00603-0. Online ahead of print.
119. Parajuli LK, Urakubo H, Takahashi-Nakazato A, Ogelman R, Iwasaki H, Koike M, Kwon HB, Ishii S, Oh WC, Fukazawa Y, Okabe S.
Geometry and the Organizational Principle of Spine Synapses along a Dendrite
eNeuro2020 Oct 27;7(6):ENEURO.0248-20.2020. doi: 10.1523/ENEURO.0248-20.2020. Print Nov-Dec 2020.
118. Okabe, S.
Regulation of actin dynamics in dendritic spines: Nanostructure, molecular mobility, and signaling mechanisms
Mol Cell Neurosci.2020 Dec;109:103564. doi: 10.1016/j.mcn.2020.103564. Epub 2020 Oct 20.
117. Okabe, S.
Recent advances in computational methods for measurement of dendritic spines imaged by light microscopy
Microscopy (Oxf). 2020 Jul 30;69(4):196-213. doi: 10.1093/jmicro/dfaa016.
116. Tanaka S, Masuda Y, Harada A, Okabe S.
Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice.
Microscopy (Oxf). 2020 Mar 9;69(1):44-52. doi: 10.1093/jmicro/dfaa001.
115. International Brain Initiative (J. Bjaalie and S. Okabe corresponding authors)
International Brain Initiative: An innovative framework for coordinated global brain research efforts.
Neuron 2020 Jan 22;105(2):212-216. doi: 10.1016/j.neuron.2020.01.002.
114. Iwasaki, K., Obashi, K., and S. Okabe
Vasodilator-stimulated phosphoprotein (VASP) is recruited into dendritic spines via G-actin-dependent mechanism and contributes to spine enlargement and stabilization.
Eur J Neurosci. 2020 Feb;51(3):806-821. doi: 10.1111/ejn.14634.
113. Cho, T., Kashiwagi, Y., and S. Okabe
Temporal sequences of synapse disintegration triggered by afferent axon transection, Time-lapse imaging study of presynaptic and postsynaptic molecules.
eNeuro. 2019 Oct 4;6(5). pii: ENEURO.0459-18.2019. doi: 10.1523/ENEURO.0459-18.2019.
112. Iguchi, R., Tanaka, S., and S. Okabe
Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex.
Neuroscience Research 2020 May;154:27-34. doi: 10.1016/j.neures.2019.05.004.
111. Li, J., Sekine-Aizawa, Y., Ebrahimi, S., Tanaka, S., and S. Okabe
Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines.
Eur J Neurosci. 2019 Aug;50(4):2722-2739. doi: 10.1111/ejn.14421.
110. Obashi, K., Matsuda, A., Inoue, Y., and S. Okabe
Precise temporal regulation of molecular diffusion within dendritic spines by actin polymers during structural plasticity.
Cell Reports 2019 Apr 30;27(5):1503-1515.e8. doi: 10.1016/j.celrep.2019.04.006.
109. Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N., Grant, S. G. N. and S. Okabe
Computational geometry analysis of dendritic spines by structured illumination microscopy.
Nature Communications 2019 Mar 20;10(1):1285. doi: 10.1038/s41467-019-09337-0.
108. Koebis M, Urata S, Shinoda Y, Okabe S, Yamasoba T, Nakao K, Aiba A, and T. Furuichi.
LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing.
Molecular Brain 2019 Mar 12;12(1):20. doi: 10.1186/s13041-019-0437-4.
107. Sadato, N., Morita, K., Kasai, K., Fukushi, T., Nakamura, K., Nakazawa, E., Okano, H., and S. Okabe.
Neuroethical issues of the Brain/MINDS project of Japan.
Neuron 2019 Feb 6;101(3):385-389. doi: 10.1016/j.neuron.2019.01.006.
Recent advances in computational methods for measurement of dendritic spines imaged by light microscopy
Microscopy (Oxf). 2020 Jul 30;69(4):196-213. doi: 10.1093/jmicro/dfaa016.
116. Tanaka S, Masuda Y, Harada A, Okabe S.
Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice.
Microscopy (Oxf). 2020 Mar 9;69(1):44-52. doi: 10.1093/jmicro/dfaa001.
115. International Brain Initiative (J. Bjaalie and S. Okabe corresponding authors)
International Brain Initiative: An innovative framework for coordinated global brain research efforts.
Neuron 2020 Jan 22;105(2):212-216. doi: 10.1016/j.neuron.2020.01.002.
114. Iwasaki, K., Obashi, K., and S. Okabe
Vasodilator-stimulated phosphoprotein (VASP) is recruited into dendritic spines via G-actin-dependent mechanism and contributes to spine enlargement and stabilization.
Eur J Neurosci. 2020 Feb;51(3):806-821. doi: 10.1111/ejn.14634.
113. Cho, T., Kashiwagi, Y., and S. Okabe
Temporal sequences of synapse disintegration triggered by afferent axon transection, Time-lapse imaging study of presynaptic and postsynaptic molecules.
eNeuro. 2019 Oct 4;6(5). pii: ENEURO.0459-18.2019. doi: 10.1523/ENEURO.0459-18.2019.
112. Iguchi, R., Tanaka, S., and S. Okabe
Neonatal social isolation increases the proportion of the immature spines in the layer 2/3 pyramidal neurons of the somatosensory cortex.
Neuroscience Research 2020 May;154:27-34. doi: 10.1016/j.neures.2019.05.004.
111. Li, J., Sekine-Aizawa, Y., Ebrahimi, S., Tanaka, S., and S. Okabe
Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines.
Eur J Neurosci. 2019 Aug;50(4):2722-2739. doi: 10.1111/ejn.14421.
110. Obashi, K., Matsuda, A., Inoue, Y., and S. Okabe
Precise temporal regulation of molecular diffusion within dendritic spines by actin polymers during structural plasticity.
Cell Reports 2019 Apr 30;27(5):1503-1515.e8. doi: 10.1016/j.celrep.2019.04.006.
109. Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N., Grant, S. G. N. and S. Okabe
Computational geometry analysis of dendritic spines by structured illumination microscopy.
Nature Communications 2019 Mar 20;10(1):1285. doi: 10.1038/s41467-019-09337-0.
108. Koebis M, Urata S, Shinoda Y, Okabe S, Yamasoba T, Nakao K, Aiba A, and T. Furuichi.
LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing.
Molecular Brain 2019 Mar 12;12(1):20. doi: 10.1186/s13041-019-0437-4.
107. Sadato, N., Morita, K., Kasai, K., Fukushi, T., Nakamura, K., Nakazawa, E., Okano, H., and S. Okabe.
Neuroethical issues of the Brain/MINDS project of Japan.
Neuron 2019 Feb 6;101(3):385-389. doi: 10.1016/j.neuron.2019.01.006.
106. Miller, C., Hale, M.E., Okano, H., Okabe, S., and Mitra, P.
Comparative principles for next-generation neuroscience.
Frontiers in Behavioral Neuroscience 2019 Feb 5;13:12. doi: 10.3389/fnbeh.2019.00012.
105. Takahashi, A., Parajuli, L.M., Iwasaki, H., Tanaka, S., and S. Okabe
Ultrastructural observation of glutamatergic synapses by focused ion beam scanning electron microscopy (FIB/SEM).
Methods in Molecular Biology 2019;1941:17-27. doi: 10.1007/978-1-4939-9077-1_2.
104. Urata, S., Iida, T., Yamamoto, M., Mizushima, Y., Fujimoto, C., Matsumoto, Y., Yamasoba, T. and S. Okabe
Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning.
eLIFE 2019 Jan 18;8. pii: e40946. doi: 10.7554/eLife.40946.
103. Iida, T., Tanaka, S., and S. Okabe
Spatial impact of microglial distribution on dynamics of dendritic spines.
European Journal of Neuroscience 2019 Jun;49(11):1400-1417. doi: 10.1111/ejn.14325. Epub 2019 Jan 16.
102. Sato, Y., and S.Okabe
Nano-scale analysis of synapse morphology in an autism mouse model with 15q11-13 copy number variation using focused ion beam milling and scanning electron microscopy.
Microscopy (Oxf). 2019 Apr 1;68(2):122-132. doi: 10.1093/jmicro/dfy128
101. Ito, H., Kawamata, Y., Kamiya, M., Tsuda, K., Tanaka, S., Ueno, T., Komatsu, T., Hanaoka, K., Okabe, S., Miura, M. and Y. Urano
Red-shifted fluorogenic substrate for detecting lacZ-positive cells in living tissue with single-cell resolution.
Angewandte Chemie Int Ed Engl. 57(48):15702-15706, 2018. doi: 10.1002/anie.201808670.
100. Tzeng, T-C, Hasegawa, Y., Iguchi, R., Caffrey, D. R., Thatcher, E. J., Mao, W.J., Germain, G., Tamburro, N. D., Okabe, S., Heneka, M., Latz, E., Futai, K.,and D. T. Golenbock
The inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer’s prone mice.
Proc. Natl. Acad. Sci. USA 115(36):9002-9007, 2018. doi: 10.1073/pnas.1801802115.
99. Nakayama, H., Abe, M., Morimoto, C., Iida, T., Okabe, S., Sakimura, K., and K. Hashimoto.
Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum.
Nature Communications 9:2830, 2018. doi: 10.1038/s41467-018-05100-z
98. Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.
Science. 359:679-684, 2018. doi: 10.1126/science.aaq1144.
97. Higashi T, Tanaka S, Iida T, and S. Okabe
Synapse elimination triggered by BMP4 exocytosis and presynaptic BMP receptor activation.
Cell Reports 22(4):919-929, 2018. doi: 10.1016/j.celrep.2017.12.101
Comparative principles for next-generation neuroscience.
Frontiers in Behavioral Neuroscience 2019 Feb 5;13:12. doi: 10.3389/fnbeh.2019.00012.
105. Takahashi, A., Parajuli, L.M., Iwasaki, H., Tanaka, S., and S. Okabe
Ultrastructural observation of glutamatergic synapses by focused ion beam scanning electron microscopy (FIB/SEM).
Methods in Molecular Biology 2019;1941:17-27. doi: 10.1007/978-1-4939-9077-1_2.
104. Urata, S., Iida, T., Yamamoto, M., Mizushima, Y., Fujimoto, C., Matsumoto, Y., Yamasoba, T. and S. Okabe
Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning.
eLIFE 2019 Jan 18;8. pii: e40946. doi: 10.7554/eLife.40946.
103. Iida, T., Tanaka, S., and S. Okabe
Spatial impact of microglial distribution on dynamics of dendritic spines.
European Journal of Neuroscience 2019 Jun;49(11):1400-1417. doi: 10.1111/ejn.14325. Epub 2019 Jan 16.
102. Sato, Y., and S.Okabe
Nano-scale analysis of synapse morphology in an autism mouse model with 15q11-13 copy number variation using focused ion beam milling and scanning electron microscopy.
Microscopy (Oxf). 2019 Apr 1;68(2):122-132. doi: 10.1093/jmicro/dfy128
101. Ito, H., Kawamata, Y., Kamiya, M., Tsuda, K., Tanaka, S., Ueno, T., Komatsu, T., Hanaoka, K., Okabe, S., Miura, M. and Y. Urano
Red-shifted fluorogenic substrate for detecting lacZ-positive cells in living tissue with single-cell resolution.
Angewandte Chemie Int Ed Engl. 57(48):15702-15706, 2018. doi: 10.1002/anie.201808670.
100. Tzeng, T-C, Hasegawa, Y., Iguchi, R., Caffrey, D. R., Thatcher, E. J., Mao, W.J., Germain, G., Tamburro, N. D., Okabe, S., Heneka, M., Latz, E., Futai, K.,and D. T. Golenbock
The inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer’s prone mice.
Proc. Natl. Acad. Sci. USA 115(36):9002-9007, 2018. doi: 10.1073/pnas.1801802115.
99. Nakayama, H., Abe, M., Morimoto, C., Iida, T., Okabe, S., Sakimura, K., and K. Hashimoto.
Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum.
Nature Communications 9:2830, 2018. doi: 10.1038/s41467-018-05100-z
98. Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.
Science. 359:679-684, 2018. doi: 10.1126/science.aaq1144.
97. Higashi T, Tanaka S, Iida T, and S. Okabe
Synapse elimination triggered by BMP4 exocytosis and presynaptic BMP receptor activation.
Cell Reports 22(4):919-929, 2018. doi: 10.1016/j.celrep.2017.12.101
96. Morimoto, M. Tanaka, S., Mizutani, S., Urata, S., Kobayashi, K. and S. Okabe
In vivo observation of structural changes in neocortical catecholaminergic projections in response to drugs of abuse.
eNeuro 6;5(1),2018. pii: ENEURO.0071-17.2018. doi: 10.1523/ENEURO.0071-17.2018. eCollection 2018 Jan-Feb.
95. Koeberle, S. C., Tanaka, S., Kuriu, T., Iwasaki, H., Koeberle, A., Schulz, A., Helbing, D., Yamagata, Y., Morrison, H., and S. Okabe
Developmental stage-dependent regulation of spine formation by calcium-calmodulin dependent protein kinase IIα and Rap1
Scientific Reports 7, 13409, 2017, doi: 10.1038/s41598-017-13728-y
94. Okabe, S.
Fluorescence imaging of synapse dynamics in normal circuit maturation and in developmental disorders.
Proceedings of the Japan Academy, Series B. 93, 483-497, 2017. doi: 10.2183/pjab.93.029
93. Yokoyama, T., Lee J-K., Miwa, K., Opthof, T., Tomoyama, S., Nakanishi, H., Yoshida, A., Yasui, H., Iida, T., Miyagawa, S., Okabe, S., Sawa, Y., Sakata, Y. and I. Komuro
Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimensional assessment of the cardiac sympathetic network in cleared transparent murine hearts.
PLoS One 12, e0182072, 2017, doi: 10.1371/journal.pone.0182072
92. Nakai, N., Nagano M., Saitow F, Watanabe W., Kawamura Y., Kawamoto A., Tamada K., Mizuma H., Onoe H., Watanabe Y., Monai H., Hirase H., Nakatani J., Inagaki H., Kawada T., Miyazaki T., Watanabe M., Sato Y., Okabe S., Kitamura K., Kano M., Hashimoto K., Suzuki H., and T. Takumi
Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.
Science Advances 3, e1603001, 2017, doi; 10.1126/sciadv.1603001
91. Hirai, S., Hotta, K., Kubo, Y., Nishino, A, Okabe, S., Okamura, Y. and H. Okado
AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate.
Proc. Natl. Acad. Sci. USA 114, 3939-3944, 2017 doi: 10.1073/pnas.1612943114
90. Parajuli, L. K., Tanaka, S., and S. Okabe
Insights into age-old questions of new dendritic spines: From form to function.
Brain Research Bulletin. 129, 3-11, 2017. pii: S0361-9230(16)30168-X. doi:10.1016/j.brainresbull.2016.07.014
89. Miyazaki, J., Tadatsune, I., Tanaka, S., Hayashi-Takagi, A., Kasai, H., Okabe, S., and T. Kobayashi
Fast 3D visualization of endogenous brain signals with high-sensitivity laser scanning photothermal microscopy.
Biomedical Optics Express 7, 1702-1710, 2016. doi: 10.1364/BOE.7.001702
88. Ochi, T., Nakatomi, H., Ito, A., Okabe, S. and N. Saito.
Temporal Changes in the response of SVZ neural stem cells to intraventricular administration of growth factors.
Brain Research 1636, 119-129, 2016. doi: 10.1016/j.brainres.2016.01.046.
87. Hayashi, A., Asanuma, D., Kamiya, M., Urano, U. and S. Okabe.
High affinity receptor labeling based on basic leucine zipper domain peptides conjugated with pH-sensitive fluorescent dye: visualization of AMPA type glutamate receptor endocytosis in living neurons.
Neuropharmacology 100, 66-75, 2016. doi: 10.1016/j.neuropharm.2015.07.026.
In vivo observation of structural changes in neocortical catecholaminergic projections in response to drugs of abuse.
eNeuro 6;5(1),2018. pii: ENEURO.0071-17.2018. doi: 10.1523/ENEURO.0071-17.2018. eCollection 2018 Jan-Feb.
95. Koeberle, S. C., Tanaka, S., Kuriu, T., Iwasaki, H., Koeberle, A., Schulz, A., Helbing, D., Yamagata, Y., Morrison, H., and S. Okabe
Developmental stage-dependent regulation of spine formation by calcium-calmodulin dependent protein kinase IIα and Rap1
Scientific Reports 7, 13409, 2017, doi: 10.1038/s41598-017-13728-y
94. Okabe, S.
Fluorescence imaging of synapse dynamics in normal circuit maturation and in developmental disorders.
Proceedings of the Japan Academy, Series B. 93, 483-497, 2017. doi: 10.2183/pjab.93.029
93. Yokoyama, T., Lee J-K., Miwa, K., Opthof, T., Tomoyama, S., Nakanishi, H., Yoshida, A., Yasui, H., Iida, T., Miyagawa, S., Okabe, S., Sawa, Y., Sakata, Y. and I. Komuro
Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimensional assessment of the cardiac sympathetic network in cleared transparent murine hearts.
PLoS One 12, e0182072, 2017, doi: 10.1371/journal.pone.0182072
92. Nakai, N., Nagano M., Saitow F, Watanabe W., Kawamura Y., Kawamoto A., Tamada K., Mizuma H., Onoe H., Watanabe Y., Monai H., Hirase H., Nakatani J., Inagaki H., Kawada T., Miyazaki T., Watanabe M., Sato Y., Okabe S., Kitamura K., Kano M., Hashimoto K., Suzuki H., and T. Takumi
Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice.
Science Advances 3, e1603001, 2017, doi; 10.1126/sciadv.1603001
91. Hirai, S., Hotta, K., Kubo, Y., Nishino, A, Okabe, S., Okamura, Y. and H. Okado
AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate.
Proc. Natl. Acad. Sci. USA 114, 3939-3944, 2017 doi: 10.1073/pnas.1612943114
90. Parajuli, L. K., Tanaka, S., and S. Okabe
Insights into age-old questions of new dendritic spines: From form to function.
Brain Research Bulletin. 129, 3-11, 2017. pii: S0361-9230(16)30168-X. doi:10.1016/j.brainresbull.2016.07.014
89. Miyazaki, J., Tadatsune, I., Tanaka, S., Hayashi-Takagi, A., Kasai, H., Okabe, S., and T. Kobayashi
Fast 3D visualization of endogenous brain signals with high-sensitivity laser scanning photothermal microscopy.
Biomedical Optics Express 7, 1702-1710, 2016. doi: 10.1364/BOE.7.001702
88. Ochi, T., Nakatomi, H., Ito, A., Okabe, S. and N. Saito.
Temporal Changes in the response of SVZ neural stem cells to intraventricular administration of growth factors.
Brain Research 1636, 119-129, 2016. doi: 10.1016/j.brainres.2016.01.046.
87. Hayashi, A., Asanuma, D., Kamiya, M., Urano, U. and S. Okabe.
High affinity receptor labeling based on basic leucine zipper domain peptides conjugated with pH-sensitive fluorescent dye: visualization of AMPA type glutamate receptor endocytosis in living neurons.
Neuropharmacology 100, 66-75, 2016. doi: 10.1016/j.neuropharm.2015.07.026.
86. Matlashov M. V., Bogdanova Y. A., Mishina N. M., Ermakova Y. G., Nikitin E. S., Balaban P. M., Okabe S., Lukyanov S., Enikolopov G., Zaraisky A. G., and Belousov VV.
Fluorescent ratiometric pH indicator SypHer2: applications in neuroscience and regenerative biology.
BBA-General Subjects 1850, 2318-2328, 2015. doi: 10.1016/j.bbagen.2015.08.002.
85. Oshiro, H., Hirabayashi, Y., Koretune, H., Nakao, K., Aizawa, S., Okabe, S. and Y. Gotoh
Upregulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex.
Genes to Cells 20, 108-120, 2015 doi: 10.1111/gtc.12205.
84. Ogura, T., Hamada, T., Matsui, T., Tanaka, S., Okabe, S., Kazama, T., and Y. Kobayashi
Neuroprotection by JM-1232(-) against oxygen-glucose deprivation-induced injury in rat hippocampal slice culture.
Brain Research 1594:52-60, 2015. doi: 10.1016/j.brainres.2014.10.038.
83. Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and S. Okabe.
Enhanced synapse remodelling as a common phenotype in mouse models of autism.
Nature Communications 5, 4742, 2014. doi: 10.1038/ncomms5742.
82. Ebrahimi, S., and S. Okabe.
Structural dynamics of dendritic spines: molecular composition, geometry and functional regulation.
BBA–Biomembranes 1838, 2391-2398. 2014. doi: 10.1016/j.bbamem.2014.06.002.
81. Ito-Ishida, A., Okabe, S. and M. Yuzaki.
The role of Cbln1 on Purkinje cell synapse formation.
Neuroscience Research 83, 64-68, 2014 doi: 10.1016/j.neures.2014.01.009.
80. Ito-Ishida, A., Kakegawa, W., Kohda, K., Miura, E., Okabe, S. and M. Yuzaki.
Cbln1 down-regulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells.
European Journal of Neuroscience 39, 1268-1280, 2014. doi: 10.1111/ejn.12487.
79. Isshiki, M. and S. Okabe
Evaluation of cranial window types for in vivo two-photon imaging of brain microstructures.
Microscopy 63, 53-63, 2014. doi: 10.1093/jmicro/dft043.
78. Dai X., Iwasaki H., Watanabe M. and S. Okabe
Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression.
European Journal of Neuroscience 39, 531-47, 2014. doi: 10.1111/ejn.12413.
77. Kondo, S. and S. Okabe
In vivo two-photon microscopy of microglia.
Methods in Molecular Biology, 1041, 319-335, 2013. doi: 10.1007/978-1-62703-520-0_28.
76. Obashi, K. and S. Okabe
Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon.
European Journal of Neuroscience 38, 2350-2363, 2013. doi: 10.1111/ejn.12263.
Fluorescent ratiometric pH indicator SypHer2: applications in neuroscience and regenerative biology.
BBA-General Subjects 1850, 2318-2328, 2015. doi: 10.1016/j.bbagen.2015.08.002.
85. Oshiro, H., Hirabayashi, Y., Koretune, H., Nakao, K., Aizawa, S., Okabe, S. and Y. Gotoh
Upregulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex.
Genes to Cells 20, 108-120, 2015 doi: 10.1111/gtc.12205.
84. Ogura, T., Hamada, T., Matsui, T., Tanaka, S., Okabe, S., Kazama, T., and Y. Kobayashi
Neuroprotection by JM-1232(-) against oxygen-glucose deprivation-induced injury in rat hippocampal slice culture.
Brain Research 1594:52-60, 2015. doi: 10.1016/j.brainres.2014.10.038.
83. Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and S. Okabe.
Enhanced synapse remodelling as a common phenotype in mouse models of autism.
Nature Communications 5, 4742, 2014. doi: 10.1038/ncomms5742.
82. Ebrahimi, S., and S. Okabe.
Structural dynamics of dendritic spines: molecular composition, geometry and functional regulation.
BBA–Biomembranes 1838, 2391-2398. 2014. doi: 10.1016/j.bbamem.2014.06.002.
81. Ito-Ishida, A., Okabe, S. and M. Yuzaki.
The role of Cbln1 on Purkinje cell synapse formation.
Neuroscience Research 83, 64-68, 2014 doi: 10.1016/j.neures.2014.01.009.
80. Ito-Ishida, A., Kakegawa, W., Kohda, K., Miura, E., Okabe, S. and M. Yuzaki.
Cbln1 down-regulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells.
European Journal of Neuroscience 39, 1268-1280, 2014. doi: 10.1111/ejn.12487.
79. Isshiki, M. and S. Okabe
Evaluation of cranial window types for in vivo two-photon imaging of brain microstructures.
Microscopy 63, 53-63, 2014. doi: 10.1093/jmicro/dft043.
78. Dai X., Iwasaki H., Watanabe M. and S. Okabe
Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression.
European Journal of Neuroscience 39, 531-47, 2014. doi: 10.1111/ejn.12413.
77. Kondo, S. and S. Okabe
In vivo two-photon microscopy of microglia.
Methods in Molecular Biology, 1041, 319-335, 2013. doi: 10.1007/978-1-62703-520-0_28.
76. Obashi, K. and S. Okabe
Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon.
European Journal of Neuroscience 38, 2350-2363, 2013. doi: 10.1111/ejn.12263.
75. Okabe, S.
Fluorescence imaging of synapse formation and remodeling.
Microscopy 62. 51-62, 2013. doi: 10.1093/jmicro/dfs083.
74. Shin, E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, J. G. and S. Okabe
Doublecortin-like kinase enhances dendritic remodeling and negatively regulates synapse maturation.
Nature Communications 4, 1440, 2013. doi: 10.1038/ncomms2443.
73. Ito-Ishida, A., Miyazaki, T., Miura, E., Matsuda, K., Watanabe, M., Yuzaki, M and S. Okabe
Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation.
Neuron 76, 549-564, 2012. doi: 10.1016/j.neuron.2012.07.027.
72. Okabe, S.
Molecular dynamics of the excitatory synapse.
Advances in Experimental Medicine and Biology 970, 131-185, 2012. doi: 10.1007/978-3-7091-0932-8_6.
71. Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A., Yanagawa, Y., and S. Okabe
LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites.
Nature Communications 3, 722, 2012. doi: 10.1038/ncomms1736.
70. Hirai S., Miwa, A., Ohtaka-Maruyama, C., Kasai M., Okabe, S., Hata, Y, and H. Okado
RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.
EMBO Journal 31, 1190-1202, 2012. doi: 10.1038/emboj.2011.486.
69. Kondo, S., Kohsaka, S. and S. Okabe
Long-term changes of spine dynamics and microglia after transient peripheral immune response triggered by LPS in vivo.
Molecular Brain 4, 27, 2011. doi: 10.1186/1756-6606-4-27.
68. Kusano K, Enomoto M, Hirai T, Wakabayashi Y, Itoh S, Ichinose S, Okabe S, Shinomiya K, and A. Okawa
Enhancement of sciatic nerve regeneration by adenovirus-mediated expression of dominant negative RhoA and Rac1.
Neuroscience Letter 492, 64-69. 2011. doi: 10.1016/j.neulet.2011.01.058.
67. Numano, F., Inoue, A., Enomoto, M., Shinomiya, K., Okawa, A., and S. Okabe
Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord.
Molecular Brain 2, 37, 2009. doi: 10.1186/1756-6606-2-37.
66. Tanaka, S., Kunii, M., Harada, A., and S. Okabe
Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts.
Genesis 47, 638-646, 2009. doi: 10.1002/dvg.20544.
65. Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T. and S. Okabe
Kinase-dead knock-in mouse reveals an essential role of CaMKII kinase activity in dendritic spine enlargement, LTP and learning.
Journal of Neuroscience, 29, 7607-7618, 2009. doi: 10.1523/JNEUROSCI.0707-09.2009.
Fluorescence imaging of synapse formation and remodeling.
Microscopy 62. 51-62, 2013. doi: 10.1093/jmicro/dfs083.
74. Shin, E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, J. G. and S. Okabe
Doublecortin-like kinase enhances dendritic remodeling and negatively regulates synapse maturation.
Nature Communications 4, 1440, 2013. doi: 10.1038/ncomms2443.
73. Ito-Ishida, A., Miyazaki, T., Miura, E., Matsuda, K., Watanabe, M., Yuzaki, M and S. Okabe
Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation.
Neuron 76, 549-564, 2012. doi: 10.1016/j.neuron.2012.07.027.
72. Okabe, S.
Molecular dynamics of the excitatory synapse.
Advances in Experimental Medicine and Biology 970, 131-185, 2012. doi: 10.1007/978-3-7091-0932-8_6.
71. Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A., Yanagawa, Y., and S. Okabe
LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites.
Nature Communications 3, 722, 2012. doi: 10.1038/ncomms1736.
70. Hirai S., Miwa, A., Ohtaka-Maruyama, C., Kasai M., Okabe, S., Hata, Y, and H. Okado
RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex.
EMBO Journal 31, 1190-1202, 2012. doi: 10.1038/emboj.2011.486.
69. Kondo, S., Kohsaka, S. and S. Okabe
Long-term changes of spine dynamics and microglia after transient peripheral immune response triggered by LPS in vivo.
Molecular Brain 4, 27, 2011. doi: 10.1186/1756-6606-4-27.
68. Kusano K, Enomoto M, Hirai T, Wakabayashi Y, Itoh S, Ichinose S, Okabe S, Shinomiya K, and A. Okawa
Enhancement of sciatic nerve regeneration by adenovirus-mediated expression of dominant negative RhoA and Rac1.
Neuroscience Letter 492, 64-69. 2011. doi: 10.1016/j.neulet.2011.01.058.
67. Numano, F., Inoue, A., Enomoto, M., Shinomiya, K., Okawa, A., and S. Okabe
Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord.
Molecular Brain 2, 37, 2009. doi: 10.1186/1756-6606-2-37.
66. Tanaka, S., Kunii, M., Harada, A., and S. Okabe
Generation of cortactin floxed mice and cellular analysis of motility in fibroblasts.
Genesis 47, 638-646, 2009. doi: 10.1002/dvg.20544.
65. Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T. and S. Okabe
Kinase-dead knock-in mouse reveals an essential role of CaMKII kinase activity in dendritic spine enlargement, LTP and learning.
Journal of Neuroscience, 29, 7607-7618, 2009. doi: 10.1523/JNEUROSCI.0707-09.2009.
64. Maruo, T., Ebihara, T., Sato, E., Kondo, S., and S. Okabe
Cre complementation with variable dimerizers for inducible expression in neurons.
Journal of Medical and Dental Sciences, 55, 247-254, 2008
63. Noda, Y., Horikawa, S, Kanda, E., Yamashita, M., Meng, H., Eto, K., Kuwahara, M., Hirai, K., Pack, C., Kinjo, M., Okabe, S., and S. Sasaki
Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking.
Journal of Cell Biology, 182, 587-601, 2008. doi: 10.1083/jcb.200709177.
62. Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Saitoh, O., Murray, R. M., Okabe, S., and H. Kunugi
Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI).
Psychiatry Research, 160, 175–183, 2008
61. Hori, H., Nagamine, M., Soshi, T., Okabe, S., Kim, Y., and H. Kunugi
Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task: A near-infrared spectroscopy study.
Neuropsychobiology, 57, 61-69, 2008
60. Nakazawa, T., Kuriu, T., Tezuka, T., Umemori, H., Okabe, S., and Yamamoto, T.
Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.
Journal of Neurochemistry, 105, 1384-1393, 2008
59. Takahashi, A., Hirai, S., Ohtaka-Maruyama, C., Miwa, A., Hata, Y., Okabe, S. and H. Okado
Co-localization of a novel transcriptional repressor simiRP58 with RP58.
Biochemical and Biophysical Research Communications, 368, 637-642, 2008
58. Hori, H., Noguchi H., Hashimoto R., Okabe S., Saitoh O., and H. Kunugi.
IQ decline and memory impairment in Japanese patients with chronic schizophrenia.
Psychiatry Research, 158, 251-255, 2008
57. Okabe, S.
Molecular anatomy of the postsynaptic density.
Molecular and Cellular Neuroscience 34, 503-518, 2007.
56. Gengyo-Ando, K., Kuroyanagi, H., Kobayashi, T., Murate, M., Fujimoto, K., Okabe, S. and S. Mitani.
The Sec1/Munc18 family protein, VPS-45, is required for RAB-5- dependent endocytic trafficking in C. elegans.
EMBO Reports 8, 152-157, 2007.
55. Nishida, H. and S. Okabe
Direct astrocytic contacts regulate local maturation of dendritic spines.
Journal of Neuroscience 27, 331-340, 2007.
54. Yoshimura, A., Fujii, R., Watanabe, Y., Okabe, S., Fukui, K., and T. Takumi
Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.
Current Biology 16, 2345-2351, 2006.
Cre complementation with variable dimerizers for inducible expression in neurons.
Journal of Medical and Dental Sciences, 55, 247-254, 2008
63. Noda, Y., Horikawa, S, Kanda, E., Yamashita, M., Meng, H., Eto, K., Kuwahara, M., Hirai, K., Pack, C., Kinjo, M., Okabe, S., and S. Sasaki
Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking.
Journal of Cell Biology, 182, 587-601, 2008. doi: 10.1083/jcb.200709177.
62. Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Saitoh, O., Murray, R. M., Okabe, S., and H. Kunugi
Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI).
Psychiatry Research, 160, 175–183, 2008
61. Hori, H., Nagamine, M., Soshi, T., Okabe, S., Kim, Y., and H. Kunugi
Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task: A near-infrared spectroscopy study.
Neuropsychobiology, 57, 61-69, 2008
60. Nakazawa, T., Kuriu, T., Tezuka, T., Umemori, H., Okabe, S., and Yamamoto, T.
Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP.
Journal of Neurochemistry, 105, 1384-1393, 2008
59. Takahashi, A., Hirai, S., Ohtaka-Maruyama, C., Miwa, A., Hata, Y., Okabe, S. and H. Okado
Co-localization of a novel transcriptional repressor simiRP58 with RP58.
Biochemical and Biophysical Research Communications, 368, 637-642, 2008
58. Hori, H., Noguchi H., Hashimoto R., Okabe S., Saitoh O., and H. Kunugi.
IQ decline and memory impairment in Japanese patients with chronic schizophrenia.
Psychiatry Research, 158, 251-255, 2008
57. Okabe, S.
Molecular anatomy of the postsynaptic density.
Molecular and Cellular Neuroscience 34, 503-518, 2007.
56. Gengyo-Ando, K., Kuroyanagi, H., Kobayashi, T., Murate, M., Fujimoto, K., Okabe, S. and S. Mitani.
The Sec1/Munc18 family protein, VPS-45, is required for RAB-5- dependent endocytic trafficking in C. elegans.
EMBO Reports 8, 152-157, 2007.
55. Nishida, H. and S. Okabe
Direct astrocytic contacts regulate local maturation of dendritic spines.
Journal of Neuroscience 27, 331-340, 2007.
54. Yoshimura, A., Fujii, R., Watanabe, Y., Okabe, S., Fukui, K., and T. Takumi
Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.
Current Biology 16, 2345-2351, 2006.
53. Hori, H., Noguchi, H., Hashimoto, R., Nakabayashi, T., Omori, M., Takahashi, S., Tsukue, R., Anami, K., Hirabayashi, N., Harada, S., Saito, O., Iwase, M., Kajimoto, O., Takeda, M., Okabe, S., H. Kunugi
Antipsychotic medication and cognitive function in schizophrenia.
Schizophrenia Research 86, 138-146, 2006.
52. Kuriu, T., Inoue, A., Bito, H., Sobue, K., and S. Okabe
Differential control of postsynaptic density scaffolds via actin-dependent and independent mechanisms.
Journal of Neuroscience 26, 7693-7706, 2006.
51. Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., and Y. Yoshihara
Telencephalin slows spine maturation.
Journal of Neuroscience, 26, 1776-1786, 2006.
50. Iki, J., Inoue, A., Bito, H., and S. Okabe
Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity.
European Journal of Neuroscience, 22, 2985-2994, 2005.
49. Sugiyama, Y., Kawabata, I., Sobue, K., and S. Okabe
Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.
Nature Methods 2, 677-684, 2005.
48. Fujii, R.*, Okabe, S.*, Urushido, T., Inoue, K., Yoshimura, A., Tachibana, T., Nishikawa, T., Hick, G. G., and T. Takumi * equal contribution
The RNA-binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
Current Biology 15, 587-593, 2005.
47. Schmandt, T., Meents, E., Gossrau, G., Gornik, V., Okabe, S., and O. Brustle
High-purity lineage selection of embryonic stem cell-derived neurons.
Stem Cells and Development 14, 55-64, 2005.
46. Yamamoto, K., Yamaguchi, M., and S. Okabe
Direct visualization of cell movement in the embryonic olfactory bulb using green fluorescent protein transgenic mice: evidence for rapid tangential migration of neural cell precursors.
Neuroscience Research, 51, 199-214, 2005.
45. Umeda, T., Ebihara, T., and S. Okabe
Simultaneous observation of stably associated presynaptic varicosities and postsynaptic spines: morphological alterations of CA3-CA1 synapses in hippocampal slice cultures.
Molecular and Cellular Neuroscience, 28, 264-274, 2005.
44. Kawabata, I., Umeda, T., Yamamoto, K., and S. Okabe
Electroporation-mediated gene transfer system applied to cultured CNS neurons.
Neuroreport, 15 971-976, 2004.
43. Nakazawa, T., Watabe, A. M., Tezuka, T., Yoshida, Y., Yokoyama, K., Umemori, H., Inoue, A., Okabe, S., Manabe, T., and T. Yamamoto.
p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPase, is involved in the NMDA receptor signaling.
Molecular Biology of the Cell, 13, 2921-2934, 2003.
Antipsychotic medication and cognitive function in schizophrenia.
Schizophrenia Research 86, 138-146, 2006.
52. Kuriu, T., Inoue, A., Bito, H., Sobue, K., and S. Okabe
Differential control of postsynaptic density scaffolds via actin-dependent and independent mechanisms.
Journal of Neuroscience 26, 7693-7706, 2006.
51. Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., and Y. Yoshihara
Telencephalin slows spine maturation.
Journal of Neuroscience, 26, 1776-1786, 2006.
50. Iki, J., Inoue, A., Bito, H., and S. Okabe
Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity.
European Journal of Neuroscience, 22, 2985-2994, 2005.
49. Sugiyama, Y., Kawabata, I., Sobue, K., and S. Okabe
Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.
Nature Methods 2, 677-684, 2005.
48. Fujii, R.*, Okabe, S.*, Urushido, T., Inoue, K., Yoshimura, A., Tachibana, T., Nishikawa, T., Hick, G. G., and T. Takumi * equal contribution
The RNA-binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
Current Biology 15, 587-593, 2005.
47. Schmandt, T., Meents, E., Gossrau, G., Gornik, V., Okabe, S., and O. Brustle
High-purity lineage selection of embryonic stem cell-derived neurons.
Stem Cells and Development 14, 55-64, 2005.
46. Yamamoto, K., Yamaguchi, M., and S. Okabe
Direct visualization of cell movement in the embryonic olfactory bulb using green fluorescent protein transgenic mice: evidence for rapid tangential migration of neural cell precursors.
Neuroscience Research, 51, 199-214, 2005.
45. Umeda, T., Ebihara, T., and S. Okabe
Simultaneous observation of stably associated presynaptic varicosities and postsynaptic spines: morphological alterations of CA3-CA1 synapses in hippocampal slice cultures.
Molecular and Cellular Neuroscience, 28, 264-274, 2005.
44. Kawabata, I., Umeda, T., Yamamoto, K., and S. Okabe
Electroporation-mediated gene transfer system applied to cultured CNS neurons.
Neuroreport, 15 971-976, 2004.
43. Nakazawa, T., Watabe, A. M., Tezuka, T., Yoshida, Y., Yokoyama, K., Umemori, H., Inoue, A., Okabe, S., Manabe, T., and T. Yamamoto.
p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPase, is involved in the NMDA receptor signaling.
Molecular Biology of the Cell, 13, 2921-2934, 2003.
42. Inoue A., and S. Okabe
The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.
Current Opinion in Neurobiology, 13, 332-340, 2003.
41. Enomoto, M., Shinomiya, K., and S. Okabe
Migration and differentiation of neural progenitor cells from two different regions of embryonic central nervous system after transplantation into the intact spinal cord.
European Journal of Neuroscience, 17, 1223-1232, 2003.
40. Ebihara, T., Kawabata, I., Usui, S., Sobue, K., and S. Okabe.
Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with GFP.
Journal of Neuroscience, 23, 2170-2181, 2003.
39. Usui, S., Konno, D., Hori, K., Maruoka, H., Okabe, S., Fujikado, T., Tano, Y., and K. Sobue.
Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin.
Journal of Biological Chemistry, 278, 10619-10628, 2003.
38. Ebihara, T., Komiya, Y., Izumi-Nakaseko, H., Adachi-Akahane, S., Okabe, S., and Okamura, Y.
Coexpression of a Cav1.2 protein lacking N-terminus and the first domain specifically suppresses L-type calcium channel activity.
FEBS Letters, 529, 203-207, 2002.
37. Okabe, S.
Birth, growth, and elimination of a single synapse.
Anatomical Science International, 77, 203-210, 2002.
36. Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Tamura, A., Kirino, T. and M. Nakafuku.
Regeneration of hippocampal pyramidal neurons by recruitment of endogenous neural progenitors: An animal model for a neuronal replacement therapy for ischemic brain injury.
Cell, 110, 429-441, 2002.
35. Okabe, S., Urushido, T., Konno, D., Okado, H., and K. Sobue.
Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels.
Journal of Neuroscience, 21, 9561-9571,2001.
34. Okabe, S., Miwa, A., and H. Okado.
Spine formation and correlated assembly of presynaptic and postsynaptic molecules.
Journal of Neuroscience, 21, 6105-6114, 2001.
33. Umeda, T. and S. Okabe
Visualizing synapse formation and remodeling: recent advances in real-time imaging of CNS synapses.
Neuroscience Research, 40,291-300, 2000.
32. Kondo, M., Okabe, S., Sumino, R., and H. Okado.
High GluR1 /GluR2 expression ratio correlates with expression of Ca2+-binding proteins in the rat forebrain neurons.
European Journal of Neuroscience, 12, 2812-2822, 2000.
The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.
Current Opinion in Neurobiology, 13, 332-340, 2003.
41. Enomoto, M., Shinomiya, K., and S. Okabe
Migration and differentiation of neural progenitor cells from two different regions of embryonic central nervous system after transplantation into the intact spinal cord.
European Journal of Neuroscience, 17, 1223-1232, 2003.
40. Ebihara, T., Kawabata, I., Usui, S., Sobue, K., and S. Okabe.
Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with GFP.
Journal of Neuroscience, 23, 2170-2181, 2003.
39. Usui, S., Konno, D., Hori, K., Maruoka, H., Okabe, S., Fujikado, T., Tano, Y., and K. Sobue.
Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin.
Journal of Biological Chemistry, 278, 10619-10628, 2003.
38. Ebihara, T., Komiya, Y., Izumi-Nakaseko, H., Adachi-Akahane, S., Okabe, S., and Okamura, Y.
Coexpression of a Cav1.2 protein lacking N-terminus and the first domain specifically suppresses L-type calcium channel activity.
FEBS Letters, 529, 203-207, 2002.
37. Okabe, S.
Birth, growth, and elimination of a single synapse.
Anatomical Science International, 77, 203-210, 2002.
36. Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Tamura, A., Kirino, T. and M. Nakafuku.
Regeneration of hippocampal pyramidal neurons by recruitment of endogenous neural progenitors: An animal model for a neuronal replacement therapy for ischemic brain injury.
Cell, 110, 429-441, 2002.
35. Okabe, S., Urushido, T., Konno, D., Okado, H., and K. Sobue.
Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels.
Journal of Neuroscience, 21, 9561-9571,2001.
34. Okabe, S., Miwa, A., and H. Okado.
Spine formation and correlated assembly of presynaptic and postsynaptic molecules.
Journal of Neuroscience, 21, 6105-6114, 2001.
33. Umeda, T. and S. Okabe
Visualizing synapse formation and remodeling: recent advances in real-time imaging of CNS synapses.
Neuroscience Research, 40,291-300, 2000.
32. Kondo, M., Okabe, S., Sumino, R., and H. Okado.
High GluR1 /GluR2 expression ratio correlates with expression of Ca2+-binding proteins in the rat forebrain neurons.
European Journal of Neuroscience, 12, 2812-2822, 2000.
31. Okabe, S., Kim, H., Miwa, A., Kuriu, T., and H. Okado.
Continual remodeling of postsynaptic density and its regulation by synaptic activity.
Nature Neuroscience, 2, 804-811, 1999.
30. Okabe, S., Miwa, A., and H. Okado.
Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit.
Journal of Neuroscience, 19, 7781-7792, 1999.
29. Okabe, S.
Gene expression in transgenic mice using neural promoters.
In “Current Protocols in Neuroscience”, editors J. Crawly, M. Rogawski, C. Gerfen,
D. Sibley, R. McKay, and P. Skolnick. John Wiley & Sons, Inc., 1999.
28. Bengzon, J., Okabe, S., Lindvall, O., and R. D. G. McKay.
Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor
subunit composition.
European Journal of Neuroscience, 11, 916-922, 1999.
27. Josephson, R., Müller, T., Pickel, J., Okabe, S., Reynolds, K., Turner, P. A.,
Zimmer, A., and R. D. G. McKay.
POU transcription factors control expression of CNS stem cell specific genes.
Development, 125, 3087-3100, 1998.
26. Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B.,
Segal, M., and R. D. G. McKay.
Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the
NMDA receptor.
Journal of Neuroscience, 18, 4177-4188, 1998.
25. Okabe, S., Vicario-Abejón, C., Segal, M., and R. D. G. McKay.
Survival and synaptogenesis of hippocampal neurons without NMDA receptor
function in culture.
European Journal of Neuroscience, 10, 2192-2198, 1998.
24. Okabe, S.
Differentiation of Embryonic Stem Cells.
In “Current Protocols in Neuroscience”, editors J. Crawly, M. Rogawski, C. Gerfen,
D. Sibley, R. McKay, and P. Skolnick. John Wiley & Sons, Inc., 1997.
23. Brüstle, O., Spiro, A.C., Karram, K., Choudhary, K., Okabe, S., and R. D. G.
McKay.
In vitro-generated neural precursors participate in mammalian brain development.
Proc. Natl. Acad. Sci. USA, 94, 14809-14814, 1997.
22. Okabe, S., Forsberg-Nilsson, K., Spiro, A. C., Segal, M. and R. D. G. McKay.
Development of neuronal precursor cells and functional postmitotic neurons from
embryonic stem cells in vitro.
Mechanisms of Development, 59, 89-102, 1996.
21. Sato-Harada, R., Okabe, S., Umeyama, T., Kanai, Y., and N. Hirokawa.
Microtubule-associated proteins regulate microtubule function as the track for
intracellular membrane organelle transports.
Cell Structure and Function, 21, 283-295, 1996.
Continual remodeling of postsynaptic density and its regulation by synaptic activity.
Nature Neuroscience, 2, 804-811, 1999.
30. Okabe, S., Miwa, A., and H. Okado.
Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit.
Journal of Neuroscience, 19, 7781-7792, 1999.
29. Okabe, S.
Gene expression in transgenic mice using neural promoters.
In “Current Protocols in Neuroscience”, editors J. Crawly, M. Rogawski, C. Gerfen,
D. Sibley, R. McKay, and P. Skolnick. John Wiley & Sons, Inc., 1999.
28. Bengzon, J., Okabe, S., Lindvall, O., and R. D. G. McKay.
Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor
subunit composition.
European Journal of Neuroscience, 11, 916-922, 1999.
27. Josephson, R., Müller, T., Pickel, J., Okabe, S., Reynolds, K., Turner, P. A.,
Zimmer, A., and R. D. G. McKay.
POU transcription factors control expression of CNS stem cell specific genes.
Development, 125, 3087-3100, 1998.
26. Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B.,
Segal, M., and R. D. G. McKay.
Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the
NMDA receptor.
Journal of Neuroscience, 18, 4177-4188, 1998.
25. Okabe, S., Vicario-Abejón, C., Segal, M., and R. D. G. McKay.
Survival and synaptogenesis of hippocampal neurons without NMDA receptor
function in culture.
European Journal of Neuroscience, 10, 2192-2198, 1998.
24. Okabe, S.
Differentiation of Embryonic Stem Cells.
In “Current Protocols in Neuroscience”, editors J. Crawly, M. Rogawski, C. Gerfen,
D. Sibley, R. McKay, and P. Skolnick. John Wiley & Sons, Inc., 1997.
23. Brüstle, O., Spiro, A.C., Karram, K., Choudhary, K., Okabe, S., and R. D. G.
McKay.
In vitro-generated neural precursors participate in mammalian brain development.
Proc. Natl. Acad. Sci. USA, 94, 14809-14814, 1997.
22. Okabe, S., Forsberg-Nilsson, K., Spiro, A. C., Segal, M. and R. D. G. McKay.
Development of neuronal precursor cells and functional postmitotic neurons from
embryonic stem cells in vitro.
Mechanisms of Development, 59, 89-102, 1996.
21. Sato-Harada, R., Okabe, S., Umeyama, T., Kanai, Y., and N. Hirokawa.
Microtubule-associated proteins regulate microtubule function as the track for
intracellular membrane organelle transports.
Cell Structure and Function, 21, 283-295, 1996.
20. Takemura, R., Okabe, S., Umeyama, T. and N. Hirokawa.
Polarity orientation and assembly process of microtubule bundles in nocodazole-treated, MAP2C-transfected COS cells.
Molecular Biology of the Cell, 6, 981-996, 1995.
19. Takeda, S., Okabe, S., Funakoshi, T. and N. Hirokawa.
Differential dynamics of neurofilament-H protein and neurofilament-L protein in
neurons.
Journal of Cell Biology, 127, 173-186, 1994.
18. Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, T., Oshima, T.,
Sato-Yoshitake, R., Takei, Y., Noda, T. and N. Hirokawa.
Altered microtubule organization in small-calibre axons of mice lacking tau protein.
Nature, 369, 488-491, 1994.
17. Miyasaka, H., Okabe, S., Ishiguro, T., Uchida, T. and N. Hirokawa.
Interaction of the tail domain of high molecular weight subunits of neurofilaments with the C-terminal region of tubulin and its regulation by tau protein kinase II.
Journal of Biological Chemistry, 268, 22695-22702, 1993.
16. Okabe, S., Miyasaka, H., and N. Hirokawa.
Dynamics of the neuronal intermediate filaments.
Journal of Cell Biology, 121, 375-386, 1993.
15. Okabe, S. and N. Hirokawa.
Do photobleached fluorescent microtubules move?:re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon.
Journal of Cell Biology, 120, 1177-1186, 1993.
14. Umeyama, T., Okabe, S., Kanai, Y. and N. Hirokawa.
Dynamics of microtubules bundled by microtubule-associated protein 2C (MAP2C).
Journal of Cell Biology, 120, 451-465, 1993.
13. Takemura, R., Okabe, S., Kobayashi, N. and N. Hirokawa.
Reorganization of brain spectrin (fodrin) during differentiation of PC12 cells.
Neuroscience, 52, 381-391, 1993.
12. Hirokawa, N. and S. Okabe.
Microtubules on the move?
Current Biology, 2, 193-195, 1992.
11. Takemura, R., Okabe, S., Umeyama, T., Kanai, Y., Cowan, N. and N.
Hirokawa.
Increased microtubule stability and -tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau.
Journal of Cell Science, 103, 953-964, 1992.
10. Oshima, T., Okabe, S. and N. Hirokawa.
Immunocytochemical localization of 205kDa microtubule-associated protein (205kDa MAP) in the guinea pig organ of Corti.
Brain Research, 590, 53-65, 1992.
9. Okabe, S. and N. Hirokawa.
Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons.
Journal of Cell Biology, 117, 105-120, 1992.
Polarity orientation and assembly process of microtubule bundles in nocodazole-treated, MAP2C-transfected COS cells.
Molecular Biology of the Cell, 6, 981-996, 1995.
19. Takeda, S., Okabe, S., Funakoshi, T. and N. Hirokawa.
Differential dynamics of neurofilament-H protein and neurofilament-L protein in
neurons.
Journal of Cell Biology, 127, 173-186, 1994.
18. Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, T., Oshima, T.,
Sato-Yoshitake, R., Takei, Y., Noda, T. and N. Hirokawa.
Altered microtubule organization in small-calibre axons of mice lacking tau protein.
Nature, 369, 488-491, 1994.
17. Miyasaka, H., Okabe, S., Ishiguro, T., Uchida, T. and N. Hirokawa.
Interaction of the tail domain of high molecular weight subunits of neurofilaments with the C-terminal region of tubulin and its regulation by tau protein kinase II.
Journal of Biological Chemistry, 268, 22695-22702, 1993.
16. Okabe, S., Miyasaka, H., and N. Hirokawa.
Dynamics of the neuronal intermediate filaments.
Journal of Cell Biology, 121, 375-386, 1993.
15. Okabe, S. and N. Hirokawa.
Do photobleached fluorescent microtubules move?:re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon.
Journal of Cell Biology, 120, 1177-1186, 1993.
14. Umeyama, T., Okabe, S., Kanai, Y. and N. Hirokawa.
Dynamics of microtubules bundled by microtubule-associated protein 2C (MAP2C).
Journal of Cell Biology, 120, 451-465, 1993.
13. Takemura, R., Okabe, S., Kobayashi, N. and N. Hirokawa.
Reorganization of brain spectrin (fodrin) during differentiation of PC12 cells.
Neuroscience, 52, 381-391, 1993.
12. Hirokawa, N. and S. Okabe.
Microtubules on the move?
Current Biology, 2, 193-195, 1992.
11. Takemura, R., Okabe, S., Umeyama, T., Kanai, Y., Cowan, N. and N.
Hirokawa.
Increased microtubule stability and -tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau.
Journal of Cell Science, 103, 953-964, 1992.
10. Oshima, T., Okabe, S. and N. Hirokawa.
Immunocytochemical localization of 205kDa microtubule-associated protein (205kDa MAP) in the guinea pig organ of Corti.
Brain Research, 590, 53-65, 1992.
9. Okabe, S. and N. Hirokawa.
Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons.
Journal of Cell Biology, 117, 105-120, 1992.
8. Okabe, S. and N. Hirokawa.
Actin dynamics in growth cones.
Journal of Neuroscience, 11, 1918-1929, 1991.
7. Okabe, S. and N. Hirokawa.
Turnover of fluorescently labelled tubulin and actin in the axon.
Nature, 343, 479-482, 1990.
6. Okabe, S. and N. Hirokawa.
Axonal transport.
Current Opinion in Cell Biology, 1, 91-97, 1989.
5. Okabe, S. and N. Hirokawa.
Incorporation and turnover of biotin-labeled actin microinjected into fibroblastic cells: an immunoelectron microscopic study.
Journal of Cell Biology, 109, 1581-1595, 1989.
4. Okabe, S. and N. Hirokawa.
Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.
Proc. Natl. Acad. Sci. USA, 86, 4127-4131, 1989.
3. Okabe, S. and N. Hirokawa.
Immunocytochemical localization of mirotubule-associated protein 1A and 2 in the rat retina.
Brain Research, 483, 335-346, 1989.
2. Hirokawa, N., Shiomura, Y., and S. Okabe.
Tau proteins: the molecular structure and mode of binding on microtubules.
Journal of Cell Biology, 107, 1449-1461, 1988.
1. Okabe, S. and N. Hirokawa.
Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells.
Journal of Cell Biology, 107, 651-664, 1988.
Actin dynamics in growth cones.
Journal of Neuroscience, 11, 1918-1929, 1991.
7. Okabe, S. and N. Hirokawa.
Turnover of fluorescently labelled tubulin and actin in the axon.
Nature, 343, 479-482, 1990.
6. Okabe, S. and N. Hirokawa.
Axonal transport.
Current Opinion in Cell Biology, 1, 91-97, 1989.
5. Okabe, S. and N. Hirokawa.
Incorporation and turnover of biotin-labeled actin microinjected into fibroblastic cells: an immunoelectron microscopic study.
Journal of Cell Biology, 109, 1581-1595, 1989.
4. Okabe, S. and N. Hirokawa.
Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.
Proc. Natl. Acad. Sci. USA, 86, 4127-4131, 1989.
3. Okabe, S. and N. Hirokawa.
Immunocytochemical localization of mirotubule-associated protein 1A and 2 in the rat retina.
Brain Research, 483, 335-346, 1989.
2. Hirokawa, N., Shiomura, Y., and S. Okabe.
Tau proteins: the molecular structure and mode of binding on microtubules.
Journal of Cell Biology, 107, 1449-1461, 1988.
1. Okabe, S. and N. Hirokawa.
Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells.
Journal of Cell Biology, 107, 651-664, 1988.