Publication List (Selected) 

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  1. Ochi T, Nakatomi H, Ito A, Imai H, Okabe S, Saito N.
    Temporal changes in the response of SVZ neural stem cells to intraventricular administration of growth factors.
    Brain Res. 1636:118-29,2016 doi: 10.1016/j.brainres.2016.01.046.
  2. Matlashov ME, Bogdanova YA, Ermakova GV, Mishina NM, Ermakova YG, Nikitin ES, Balaban PM, Okabe S, Lukyanov S, Enikolopov G, Zaraisky AG, Belousov VV.
    Fluorescent ratiometric pH indicator SypHer2: Applications in neuroscience and regenerative biology.
    Biochim Biophys Acta. 1850(11):2318-28, 2015 doi: 10.1016/j.bbagen.2015.08.002.
  3. Hayashi A, Asanuma D, Kamiya M, Urano Y, Okabe S.
    High affinity receptor labeling based on basic leucine zipper domain peptides conjugated with pH-sensitive fluorescent dye: Visualization of AMPA-type glutamate receptor endocytosis in living neurons.
    Neuropharmacology. 100:66-75, 2016 doi: 10.1016/j.neuropharm.2015.07.026.
  4. Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and S. Okabe
    Enhanced synapse remodelling as a common phenotype in mouse models of autism.
    Nature Communications 5, 4742, 2014.
  5. Obashi, K. and Okabe, S.
    Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon.
    European Journal of Neuroscience 38(3), 2350-2363, 2013.
    →Commentary on this paper
  6. Okabe, S.
    Fluorescence imaging of synapse formation and remodeling.

    Microscopy 62(1), 51-62, 2013.
  7. Shin E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, G.J., S. Okabe
    Doblecortin-like kinase enhances dendrite remodelling and negatively regulates synapse maturation
    Nature Communications 4, 1440, 2013.
  8. Ito-Ishida A, Miyazaki T, Miura E, Matsuda K, Watanabe M, Yuzaki M and S. Okabe
    Presynaptically Released Cbln1 Induces Dynamic Axonal Structural Changes
    by Interacting with GluD2 during Cerebellar Synapse Formation.

    Neuron 76, 549-64, 2012.
  9. Okabe, S.
    Molecular dynamics of the excitatory synapse.
    Advances in Experimental Medicine and Biology 970, 131-185, 2012.
  10. Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A., Yanagawa, Y., and S. Okabe
    LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites.
    Nature Communications 3, 722, 2012.
  11. Kondo, S., Kohsaka, S., and S. Okabe
    Long-term changes of spine dynamics and microglia after transient peripheral immune response triggered by LPS in vivo.
    Molecular Brain 4, 27, 2011.
  12. Numano, F., Inoue, A., Enomoto, M., Shinomiya, K., Okawa, A., and S. Okabe
    Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord.
    Molecular Brain 2, 37, 2009.
  13. Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T. and S. Okabe
    Kinase-dead knock-in mouse reveals an essential role of CaMKIIa kinase activity in dendritic spine enlargement, LTP and learning.
    Journal of Neuroscience, 29, 7607-7618, 2009.
  14. Okabe, S.
    Molecular anatomy of the postsynaptic density.
    Molecular and Cellular Neuroscience 34, 503-518, 2007.
  15. Gengyo-Ando, K., Kuroyanagi, H., Kobayashi, T., Murate, M., Fujimoto, K., Okabe, S. and S. Mitani
    The Sec1/Munc18 family protein, VPS-45, is required for RAB-5- dependent endocytic trafficking in C. elegans.
    EMBO Reports 8, 152-157, 2007.
  16. Nishida, H. and S. Okabe
    Direct astrocytic contacts regulate local maturation of dendritic spines.
    Journal of Neuroscience 27, 331-340, 2007.
    ["Faculty of 1000" に "Must Read Paper" として紹介されました (PDF)]
  17. Yoshimura, A., Fujii, R., Watanabe, Y., Okabe, S., Fukui, K., and T. Takumi
    Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines.
    Current Biology 16, 2345-2351, 2006.
  18. Kuriu, T., Inoue, A., Bito, H., Sobue, K., and S. Okabe
    Differential control of postsynaptic density scaffolds via actin-dependent and independent mechanisms.
    Journal of Neuroscience 26, 7693-7706, 2006.
  19. Matsuno, H., Okabe, S., Mishina, M., Yanagida, T., Mori, K., and Y. Yoshihara
    Telencephalin slows spine maturation.
    Journal of Neuroscience
    26, 1776-1786, 2006.
  20. Iki, J., Inoue, A., Bito, H., and S. Okabe
    Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity.
    European Journal of Neuroscience
    22, 2985-2994, 2005.
  21. Sugiyama, Y., Kawabata, I., Sobue, K., and S. Okabe
    Determination of absolute protein numbers in single synapses by a GFP-based calibration technique.
    Nature Methods 2, 677-684, 2005.
  22. Fujii, R.*, Okabe, S.*, Urushido, T., Inoue, K., Yoshimura, A., Tachibana, T., Nishikawa, T., Hick, G. G., and T. Takumi * equal contribution
    The RNA-binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
    Current Biology 15, 587-593, 2005.
  23. Yamamoto, K., Yamaguchi, M., and S. Okabe
    Direct visualization of cell movement in the embryonic olfactory bulb using green fluorescent protein transgenic mice: evidence for rapid tangential migration of neural cell precursors.
    Neuroscience Research, 51, 199-214, 2005.
  24. Umeda, T., Ebihara, T., and S. Okabe
    Simultaneous observation of stably associated presynaptic varicosities and postsynaptic spines: morphological alterations of CA3-CA1 synapses in hippocampal slice cultures.
    Molecular and Cellular Neuroscience, 28, 264-274, 2005.
  25. Nakazawa, T., Watabe, A. M., Tezuka, T., Yoshida, Y., Yokoyama, K., Umemori, H., Inoue, A., Okabe, S., Manabe, T., and T. Yamamoto.
    p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPase, is involved in the NMDA receptor signaling.
    Molecular Biology of the Cell, 13, 2921-2934, 2003.
  26. Inoue A., and S. Okabe
    The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.
    Current Opinion in Neurobiology, 13, 332-340, 2003.
  27. Ebihara, T., Kawabata, I., Usui, S., Sobue, K., and S. Okabe.
    Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with GFP.
    Journal of Neuroscience, 23, 2170-2181, 2003.
  28. Usui, S., Konno, D., Hori, K., Maruoka, H., Okabe, S., Fujikado, T., Tano, Y., and K. Sobue.
    Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin.
    Journal of Biological Chemistry, 278, 10619-10628, 2003.
  29. Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Tamura, A., Kirino, T. and M. Nakafuku.
    Regeneration of hippocampal pyramidal neurons by recruitment of endogenous neural progenitors: An animal model for a neuronal replacement therapy for ischemic brain injury .
    Cell, 110, 429-441, 2002.
  30. Okabe, S., Urushido, T., Konno, D., Okado, H., and K. Sobue.
    Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels.
    Journal of Neuroscience, 21,9561-9571,2001.
  31. Okabe, S., Miwa, A., and H. Okado.
    Spine formation and correlated assembly of presynaptic and postsynaptic molecules.
    Journal of Neuroscience, 21, 6105-6114, 2001.
  32. Okabe, S., Kim, H., Miwa, A., Kuriu, T., and H. Okado.
    Continual remodeling of postsynaptic density and its regulation by synaptic activity.
    Nature Neuroscience, 2, 804-811, 1999.
  33. Okabe, S., Miwa, A., and H. Okado.
    Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit.
    Journal of Neuroscience, 19, 7781-7792, 1999.
  34. Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B.,
    Segal, M., and R. D. G. McKay.
    Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor.
    Journal of Neuroscience, 18, 4177-4188, 1998.
  35. Brustle, O., Spiro, A.C., Karram, K., Choudhary, K., Okabe, S., and R. D. G.
    McKay.
    In vitro-generated neural precursors participate in mammalian brain development.
    Proc. Natl. Acad. Sci. USA, 94, 14809-14814, 1997.
  36. Okabe, S., Forsberg-Nilsson, K., Spiro, A. C., Segal, M. and R. D. G. McKay.
    Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.
    Mechanisms of Development, 59, 89-102, 1996.
  37. Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, T., Oshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T. and N. Hirokawa.
    Altered microtubule organization in small-calibre axons of mice lacking tau protein.
    Nature, 369, 488-491, 1994.
  38. Okabe, S., Miyasaka, H., and N. Hirokawa.
    Dynamics of the neuronal intermediate filaments.
    Journal of Cell Biology, 121, 375-386, 1993.
  39. Okabe, S. and N. Hirokawa.
    Do photobleached fluorescent microtubules move?:re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon.
    Journal of Cell Biology, 120, 1177-1186, 1993.
  40. Okabe, S. and N. Hirokawa.
    Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons.
    Journal of Cell Biology, 117, 105-120, 1992.
  41. Okabe, S. and N. Hirokawa.
    Actin dynamics in growth cones.
    Journal of Neuroscience, 11, 1918-1929, 1991.
  42. Okabe, S. and N. Hirokawa.
    Turnover of fluorescently labelled tubulin and actin in the axon.
    Nature, 343, 479-482, 1990.
  43. Okabe, S. and N. Hirokawa.
    Incorporation and turnover of biotin-labeled actin microinjected into fibroblastic cells: an immunoelectron microscopic study.
    Journal of Cell Biology, 109, 1581-1595, 1989.
  44. Okabe, S. and N. Hirokawa.
    Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons.
    Proc. Natl. Acad. Sci. USA, 86, 4127-4131, 1989.
  45. Okabe, S. and N. Hirokawa.
    Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells.
    Journal of Cell Biology, 107, 651-664, 1988.
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